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Canker Sore Treatment

Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):500-4.Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration.

Jiang XW, Zhang Y, Song GD, Li FF, Peng HY, Yang SK, Sun GL.

Source

Department of Stomatology, the First People's Hospital of Chenzhou, Chenzhou, China.

Abstract

OBJECTIVE:

We investigated the effectiveness and safety of topical application of 5 mg allicin adhesive tablets in the treatment of minor recurrent aphthous ulcerations (MiRAU), or canker sores.

MATERIAL AND METHODS:

A randomized, double-blinded, placebo-controlled, clinical trial was performed. Tablets containing 5 mg allicin or vehicle only were consecutively applied 4 times per day for 5 days. The size and pain level of canker sores ulcers were measured and recorded on days 1, 2, 4, and 6.

RESULTS:

A total of 96 subjects with MiRAU fulfilled the study. Allicin adhesive tablets significantly reduced canker sore size (P < .005, P < .003, P < .001 for days 2, 4, and 6, respectively) and alleviated canker pain score (P < .03, P < .001, P < .05 for days 2, 4, and 6, respectively) compared with vehicle tablets. Minor and major adverse reactions were not observed.

CONCLUSIONS:

Allicin adhesive tablets were effective in reducing canker sore ulcer size and alleviating canker sore pain of the patients in the treatment of MiRAU without significant side effects.

Crown Copyright © 2012. Published by Mosby, Inc. All rights reserved.

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Am J Dent. 2012 Feb;25(1):39-43.

Topical lavender oil for the treatment of recurrent aphthous ulceration.

Altaei DT.

Source

Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, 100 Metry - near Rizgary Hospital, Erbil City, Kurdistan, Northern Iraq, Iraq. tagreedaltaei@yahoo.com

Abstract

PURPOSE:

To determine the laboratory and clinical efficacy of lavender oil in the treatment of recurrent aphthous ulceration (RAU) or canker sores.

METHODS:

This was a randomized double-blind, placebo-controlled study performed firstly to treat the induced canker sore ulcers by different methods in experimental animals (rabbits) treated with lavender oil or placebo. Clinical and histological healing was established by measuring the area of the canker sore and inflammation levels in each test group. Secondly, safety/toxicity; the median lethal dose (LD50) was studied in albino mice, and dermal irritation test was performed by primary irritation to the skin and measured by a patch-test technique on the intact skin of the albino rabbit. Thirdly, antibacterial effect; lavender oil was screened against bacteria obtained from swab specimen of human subjects' RAU (canker sore) using disc diffusion method. Fourthly, clinical study; 115 subjects (mean age 38 years, mean weight 75 kg) were divided into two groups of subjects topically treated with lavender oil or placebo. The clinical efficacy was assessed by inflammation level, erythema, edema, canker sore duration, canker sore ulcer size, mean area under the curve of canker sore area, healing time, and associated pain intensity and reduction.

RESULTS:

Animals treated with lavender oil showed a significant canker sore ulcer size reduction, increased rate of mucosal repair, and healing within 3 days of treatment compared to baseline and placebo groups [2-3 days (90%), 4 days (10%)] (P=0.001). The intraperitoneal LD50 value in mice was 6.5 gm/kg; clinical dermal irritation test showed no sign of irritation in the tested products. Lavender oil showed a broad antibacterial activity against all tested strains; it exhibited significant inhibition on tested bacteria where the value of zone of inhibition ranged from 14.5-24 mm vs Streptomycin (25 microg/disc) 12-22 +/- 0.5 mm; MIC was > 6.4-36 mg/ml. Canker sore patients treated with lavender oil showed a significant reduction in inflammation level, canker sore size, healing time, from 2-4 days [2 days (40%), 3 days (50%), 4 days (10%)], and pain relief mostly from the first dose, compared to baseline and placebo. No side effects were reported.

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J Am Dent Assoc. 2012 Apr;143(4):370-6.

Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial.

Lalla RV, Choquette LE, Feinn RS, Zawistowski H, Latortue MC, Kelly ET, Baccaglini L.

Source

Section of Oral Medicine, University of Connecticut Health Center, Farmington, Conn. 06030-1605, USA. lalla@uchc.edu

Abstract

BACKGROUND:

Recurrent aphthous stomatitis (RAS) canker sores is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause.

METHODS:

The authors conducted a single-center, randomized, parallel-arm, double-masked, placebo-controlled study to examine the effect of daily multivitamin supplementation on the number and duration of canker sore episodes. The authors randomly assigned 160 adults who had a validated history of at least three episodes of idiopathic minor RAS canker sores within the previous 12 months to one of two groups: the first group (n = 83) received a once-daily multivitamin containing 100 percent of the U.S. reference daily intake (RDI) of essential vitamins, and the second group (n = 77) received once-daily placebo for up to 365 days.

RESULTS:

The results showed no significant difference in the mean number of new canker sore episodes between the multivitamin (4.19 episodes) and placebo (4.60 episodes) arms during the study period (P = .69). The mean duration of new canker sore episodes also was similar for the multivitamin (8.66 days) and placebo (8.99 days) arms (P = .60). Furthermore, the authors found no differences between the two arms with regard to mouth pain, normalcy of diet or compliance with the study medication regimen.

CONCLUSION:

Daily multivitamin supplementation, with the RDI of essential vitamins, did not result in a reduction in the number or duration of RAS canker sore episodes.

CLINICAL IMPLICATIONS:

Clinicians should not recommend multi-vitamin supplementation routinely as prophylaxis for RAS (frequent canker sores).

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Am J Med. 2012 Mar;125(3):292-301.

Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration.

Liu C, Zhou Z, Liu G, Wang Q, Chen J, Wang L, Zhou Y, Dong G, Xu X, Wang Y, Guo Y, Lin M, Wu L, Du G, Wei C, Zeng X, Wang X, Wu J, Li B, Zhou G, Zhou H.

Source

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.

Abstract

OBJECTIVE:

Recurrent aphthous ulceration - frequent canker sores is the most common oral mucosal lesion and may be associated with many systemic diseases. Topical corticosteroids are used frequently for frequent recurrent canker sore ulceration; however, the number of high-quality clinical experiments available is insufficient, and no reports exist on the blood level of corticosteroids after topical usage in the oral mucosa. The objective was to determine the efficacy and safety of dexamethasone ointment in the treatment of recurrent aphthous (canker sore) ulceration and detect serum dexamethasone concentrations in the patients.

METHODS:

A randomized, double-blinded, placebo-controlled, parallel, multicenter clinical trial was conducted in 5 centers to compare the efficacy and safety of dexamethasone ointment with placebo. There were 810 patients with minor canker sore ulcerations screened for study eligibility, and 240 patients were enrolled at 5 centers from March 1, 2009 to April 30, 2010; 120 were assigned randomly to the treatment group and 120 to a control group. Patients were instructed to apply the given agent to the identified canker sore 3 times a day (after meals) for 5 days. The size, pain level, healing ratio, and average duration of canker sores and the safety of the agents were evaluated. The serum concentration of dexamethasone was detected using a high-performance liquid chromatography/mass spectrometry assay.

RESULTS:

The results showed that baseline characteristics were similar (P>.5). At day 6 ± 2 after treatment, there was significant difference in the variation of canker sore ulcer size between the treatment group (7.167 ± 6.3415 mm(2)) and the control group (4.346 ± 7.0666 mm(2); P = .000); and in the variation of pain level between the treatment group (5.623 ± 1.9570) and the control group (4.940 ± 2.2449; P = .001). The healing ratio was 83.33% in the treatment group and 54.70% in the control group (P = .000). No severe adverse reactions were observed. No serum dexamethasone was detected before or after the use of the agents (<0.502 ng/mL).

CONCLUSION:

Dexamethasone ointment was efficient in the treatment of recurrent aphthous canker sore ulceration and was safe as evaluated using clinical assessment and serum level detection.

Copyright © 2012 Elsevier Inc. All rights reserved.

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J Orofac Pain. 2011 Fall;25(4):327-32.

Efficacy of topical 1% lidocaine in the symptomatic treatment of pain associated with oral mucosal trauma or minor oral aphthous ulcer: a randomized, double-blind, placebo-controlled, parallel-group, single-dose study.

Descroix V, Coudert AE, Vigé A, Durand JP, Toupenay S, Molla M, Pompignoli M, Missika P, Allaert FA.

Source

Faculté de Chirugie Dentaire, Université Paris Diderot, Paris, France. vianney.descroix@free.fr

Abstract

AIMS:

To determine the efficacy in pain reduction of a topical 1% lidocaine compared to a placebo cream in patients with oral mucosal lesions due to trauma or minor oral aphthous canker sore ulcer.

METHODS:

The design was a double-blind, randomized, placebo-controlled, six-center trial on 59 patients. Pain intensity and relief were measured using a 100-mm visual analog scale (VAS). One-tailed Student t test and ANOVA analyses were used for statistical analyses.

RESULTS:

Independent of the pain origin (oral mucosal trauma or minor canker sore), the application of the 1% lidocaine cream led to a mean reduction in VAS pain intensity of 29.4 mm ± 17.0, which was significantly greater than the decrease obtained with the placebo cream. Analysis showed a statistically significant efficacy of the 1% lidocaine cream (P = .0003). Its efficacy was not related to the type of lesion, and no adverse drug reaction, either local or systemic, was reported by any of the patients.

CONCLUSION:

A significant reduction in pain intensity occurred after application of 1% lidocaine cream and was significantly greater than that with the placebo cream. Taking into account the study's limitations, this product seems safe to use.


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